WebA few mathematical models have been proposed to explain the dynamics of subsets of the network, but the mechanistic bases remain controversial. This review focuses on outstanding problems with the generation of somitogenesis clock WebA few mathematical models have been proposed to explain the dynamics of subsets of the network, but the mechanistic bases remain controversial. This review focuses on …

Understanding the somitogenesis clock: What’s missing?

WebMar 16, 2024 · This Clock and Wavefront model, first advanced by Cooke and Zeeman in 1976 , proposes that periodic genetic oscillations (the segmentation clock) couple with a determination front moving posteriorly and stop oscillating. WebDec 21, 2024 · Our research demonstrates that the major patterning modules that are involved in somitogenesis, including the clock and wavefront, anteroposterior polarity … sarah meredith whitten

A Mechanical Model of Early Somite Segmentation

WebMar 23, 2014 · The mechanism by which Notch and FGF initiate somitogenesis, define somite polarity, and direct cell fate is called the differentiation wavefront model. Mice that have Notch genes knocked out exhibit somites with reversed polarity , resulting in tissues derived from somites being upside-down in regards to their normal position in the embryo. WebSomitogenesis, the sequential formation of a periodic pattern along the antero-posterior axis of vertebrate embryos, is one of the most obvious ... In this article, we develop a mathematical formulation of a new version of the Clock and Wavefront model proposed by Pourquié and co-workers (Dubrulle, J., McGrew, M.J., Pourquié, O., 2001. FGF ... WebJul 1, 2008 · Here we present evidence that in all of these species a similar ‘clock-and-wavefront’ 1,2,3 mechanism operates to control somitogenesis; in all of them, somitogenesis is brought to an end ... sarah meyers brent growth and decay