Cytoplasmic phospholipase a2
WebMay 5, 2005 · Introduction. Lipid requirements of the mammal are met by dietary intake and de novo synthesis; the omega-6 fatty acids (ω-6 FAs) are essential since they cannot be synthesized by mammals and must be supplied in the diet. Linoleic acid (LA) and its product, arachidonic acid (AA) are transformed into prostaglandins (PG) and thromboxanes (TX) … WebCytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene. [5] [6] Function [ edit] This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids.
Cytoplasmic phospholipase a2
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WebMar 23, 2005 · Our focus is on the Ca 2+ -sensitive form, referred to as cytoplasmic phospholipase A 2 α (cPLA 2 α), which is ubiquitously expressed in most tissues and preferentially hydrolyzes phospholipids in the sn -2 position (10). cPLA 2 plays a central role in cytokine-induced release of arachidonic acid (11). WebJan 1, 2001 · Durstin M, Durstin S, Molski TF, Becker EL, Sha'afi RI. Cytoplasmic phospholipase A2 translocates to membrane fraction in human neutrophils activated by stimuli that phosphorylate mitogen-activated protein kinase. Proc Natl Acad Sci U S A. 1994 Apr 12; 91 (8):3142–3146. [PMC free article] [Google Scholar]
WebMar 31, 2003 · Francis Berenbaum, Lydie Humbert, Gilbert Bereziat, Sylvie Thirion, Concomitant Recruitment of ERK1/2 and p38 MAPK Signalling Pathway Is Required for Activation of Cytoplasmic Phospholipase A 2 via ATP in Articular Chondrocytes , Journal of Biological Chemistry, 10.1074/jbc.M211570200, 278, 16, (13680-13687), (2003). WebRecent studies have suggested that abnormal lipid metabolism, inflammatory injury, and dysfunction of the vascular endothelial cells may be centrally linked to HDP. 5,6 Lp-PLA2 is a member of the phospholipase A2 (PLA2) superfamily, with the human gene located on chromosome 6p12-21.1 and consisting of 441 amino acids. 14 It was found that Lp ...
WebMar 23, 2005 · Our focus is on the Ca 2+-sensitive form, referred to as cytoplasmic phospholipase A 2 α (cPLA 2 α), which is ubiquitously expressed in most tissues and … WebCytosolic phospholipase A 2 (cPLA2) is a calcium-dependent enzyme that cleaves fatty acids, such as arachidonic acid, from phospholipids by hydrolyzing the SN-2 acyl bond …
WebApr 1, 2005 · Characterization of cytoplasmic phospholipase A2 mice. Generation of the cPLA 2 null line has been previously described (37). Briefly, targeted inactivation of the …
WebJan 15, 2000 · Sepsis is defined as the systemic inflammatory response to infection. Phospholipase A 2 (PLA 2) plays an important role in inflammation processes by initiating the production of inflammatory mediators.The role of cytosolic PLA (cPLA 2) has not yet been identified in inflammatory and infectious disease clinical settings.The aim of the … cityexperiences.com chicagoIncreased phospholipase A 2 has also been associated with neuropsychiatric disorders such as schizophrenia and pervasive developmental disorders (such as autism), though the mechanisms involved are not known. Isozymes. Human phospholipase A 2 isozymes include: Group I: PLA2G1B; Group II: … See more The enzyme phospholipase A2 (EC 3.1.1.4, PLA2, systematic name phosphatidylcholine 2-acylhydrolase) catalyse the cleavage of fatty acids in position 2 of phospholipids, hydrolyzing the bond between the … See more Phospholipases A2 include several unrelated protein families with common enzymatic activity. Two most notable families are secreted and cytosolic phospholipases A2. … See more PLA2 action can release histamine from rat peritoneal mast cells. It also causes histamine release in human basophils. See more In normal brain cells, PLA2 regulation accounts for a balance between arachidonic acid's conversion into proinflammatory mediators and its reincorporation into … See more The suggested catalytic mechanism of pancreatic sPLA2 is initiated by a His-48/Asp-99/calcium complex within the active site. The calcium ion polarizes the sn-2 carbonyl oxygen while also coordinating with a catalytic water molecule, w5. His … See more Due to the importance of PLA2 in inflammatory responses, regulation of the enzyme is essential. cPLA2 is regulated by phosphorylation and calcium concentrations. cPLA2 is phosphorylated by a MAPK at Serine-505. When phosphorylation is … See more Human phospholipase A2 isozymes include: • Group I: PLA2G1B • Group II: PLA2G2A, PLA2G2C, PLA2G2D, PLA2G2E, PLA2G2F • Group III: PLA2G3 See more city experiences discountWebMar 27, 2024 · The effect of sPLA2 on human lymphatic endothelial cells was investigated by culturing human lymphatic endothelial cells. Secretory phospholipases A2 (sPLA2) showed high expression levels in lymphoedema tissues, however, cytoplasmic phospholipases A2 (cPLA2), showed low expression in lymphoedema, as demonstrated … city experts belgradeWebApr 12, 1994 · Cytoplasmic phospholipase A2 translocates to membrane fraction in human neutrophils activated by stimuli that phosphorylate mitogen-activated protein … dictionary\u0027s qxWebApr 1, 2005 · In the following study, we evaluated the influence of genetic deletion of a key intracellular phospholipase, cytoplasmic PLA 2 (cPLA 2 ), on azoxymethane-induced colon tumorigenesis. cityexperiences.com statue of libertydictionary\u0027s qwWebNational Center for Biotechnology Information dictionary\u0027s qy