WebPreviously, D2HGDH was reported to decrease 2-hydroxyglutarate level in breast carcinoma cells, but no other report has examined D2HGDH in breast carcinoma, and … WebD2HGDH Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, D2HGDH Genome Browser, D2HGDH References D2HGDH - Explore an overview of …
(PDF) D2HGDH regulates alpha-ketoglutarate levels …
WebOct 7, 2024 · These studies demonstrate 2-HG is involved in pathological conditions not limited to cancer. Here, we examined the relationship between mutant IDH1 and ferroptosis sensitivity in response to... WebApr 8, 2024 · Upon the addition of D2HG, D2HGDH catalyzed the dehydrogenation of D2HG, while the electrons produced were transferred to the electrode via MB. This sensor displayed a remarkable linear response, with a D2HG concentration over the range of 0.5–120 µM, and successfully detected the levels of D2HG in fetal bovine serum and … floor ice machine
D-2-hydroxyglutarate is essential for maintaining oncogenic …
WebThe different types of 2-hydroxyglutaric aciduria result from mutations in several genes. D-2-HGA type I is caused by mutations in the D2HGDH gene; type II is caused by mutations in the IDH2 gene. L-2-HGA results from mutations in the L2HGDH gene. Combined D,L-2-HGA is caused by mutations in the SLC25A1 gene.. The D2HGDH and L2HGDH genes … WebMay 23, 2011 · A recent report identified heterozygous germline IDH2 mutations in patients with idiopathic D-2-hydroxyglutaric aciduria, carrying no mutations in D2HGDH and consistently increased D-2HG levels in body fluids [23]; interestingly, the patient did not develop brain tumours. WebJan 7, 2024 · Our data link D2HGDH to cancer and describe an additional role for the enzyme: the regulation of IDH2 activity and a-KG-mediated epigenetic remodelling. These data further expose the intricacies ... floor in a day