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Insulinoma-associated protein 1a

Nettet23. jan. 2024 · Insulinoma-associated protein 1 (INSM1), a 510–amino acid protein with 5 zinc finger motifs at the carboxyl terminus, is a developmentally regulated transcription factor involved in the development of neuroendocrine differentiation. 1, 2 Its complementary DNA, known as insulinoma-associated 1 (IA-1), was isolated in 1992 … NettetUse: Diagnosis of Type 1 Diabetes: The presence of autoantibodies against IA-2 (IA-2A) in patients with diabetes mellitus indicates the presence of autoimmune, type 1 diabetes. Prediction of Type 1 Diabetes: Autoantibodies against IA-2 (IA-2A) in an asymptomatic …

Insulinoma‐associated 1: A novel nuclear marker in Merkel cell ...

NettetEnter the email address you signed up with and we'll email you a reset link. Nettet12. feb. 2024 · Insulinoma associated-1 (INSM1) is a key protein functioning as a transcriptional repressor in neuroendocrine differentiation and is activated by N-Myc in human neuroblastoma (NB). gpib address number https://pipermina.com

Insulinoma Associated-2 Autoantibodies (IA-2A)

Nettet1. mar. 2024 · Insulinoma‑associated protein 1 (INSM1) is a useful neuro‑ endocrine marker for various neuroendocrine tumours. α‑thalassemia/mental retardation syndrome X‑linked protein (ATRX) and death domain‑associated protein (DAXX) are useful prognostic markers for patients with pancreatic neuroendocrine tumours. However, to … NettetInsulinoma-associated-1 (IA-1 or INSM1) encodes a zinc-finger transcription factor, which was isolated from a human insulinoma subtraction library, with specific expression patterns, predominantly in developing neuroendocrine tissues and tumors. INSM1 is … NettetInsulinoma-associated protein 1 (INSM1) is expressed exclusively in embryonic developing neuroendocrine (NE) tissues. INSM1 gene expression is specific for small-cell lung cancer (SCLC), along with achaete-scute homolog-like 1 (ASCL1) and several NE … childtown shelbyville

Insulinoma-associated protein 1 is a sensitive and specific ... - PubMed

Category:Insulinoma - Wikipedia

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Insulinoma-associated protein 1a

Insulinoma-Associated-1: From Neuroendocrine Tumor Marker to Cancer ...

Nettet6. okt. 2024 · Herein, we describe the first cases of neuroendocrine (NE) phenotype mammary carcinomas in which the NE nature of the tumors was confirmed only by insulinoma-associated protein 1 (INSM1), without expressions of traditional “gold … Nettet23. jun. 2024 · Insulinoma-associated protein 1 (INSM1) is a zinc finger transcription factor encoded by complementary DNA (also called IA-1) that was originally isolated from a subtraction library constructed from human insulinoma and glucagonoma. 3 INSM1 plays an important role in the development of neuroendocrine differentiation in various …

Insulinoma-associated protein 1a

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Nettetinsulinoma-associated 1a Symbol insm1a Nomenclature History Previous Names. zgc:77257; Type protein_coding_gene ... Protein Length Insulinoma-associated protein 1/2 Zinc finger C2H2 superfamily Zinc finger C2H2-type; UniProtKB:F8W3Z6. InterPro 373: UniProtKB:Q6P0F9. InterPro ... Nettet27. feb. 2024 · The deduced 566-amino acid protein contains an SNAI1/GFI1 motif followed by 2 proline-rich sequences in its N-terminal half and 5 C2H2-type zinc fingers in its C-terminal half. INSM2 shares 51% amino acid identity with INSM1. Northern blot analysis detected a 4.8-kb INSM2 transcript that was highly expressed in heart and …

Nettet将微管关联蛋白1a(map1a)抗体包被于96孔微孔板中，制成固相载体，向微孔中分别加入标准品或标本，其中的微管关联蛋白1a(map1a)与连接于固相载体上的抗体结合，然后加入生物素化的微管关联蛋白1a(map1a)抗体，将未结合的生物素化抗体洗净后，加入hrp标记的亲和素，再次彻底洗涤后加入tmb底物显色。 NettetLOC106468100 insulinoma-associated protein 1a-like [ (Atlantic horseshoe crab)] Gene ID: 106468100, updated on 4-Feb-2024. Summary Other designations. insulinoma-associated protein 1a-like

Nettet17. nov. 2024 · Sanjay Mukhopadhyay, Josephine K. Dermawan, Christopher P. Lanigan, Carol F. Farver, Insulinoma-associated protein 1 (INSM1) is a sensitive and highly specific marker of neuroendocrine differentiation in primary lung neoplasms: an immunohistochemical study of 345 cases, including 292 whole-tissue sections, Modern … NettetIslet cell autoantibodies have been known to be associated with type 1 diabetes mellitus for many years. In recent years, several autoantigens against which islet antibodies are directed have been identified. These include the tyrosine phosphatase-related islet antigen 2 (IA-2), glutamic acid decarboxylase 65, zinc transporter 8, and insulin.

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Nettet1. aug. 2024 · Insulinoma-associated-1 (IA-1 or INSM1) is a zinc-finger transcription factor that was identified in a human insulinoma subtraction library, from which it was isolated ().Insm1 is an intronless gene encoding a 510-amino acid protein that contains 5 zinc-finger DNA-binding motifs and several potential functional domains ().This novel … gpi battle creek millNettet24. jul. 2024 · Insulinoma is a type of functional neuroendocrine tumor characterized by hypersecretion of insulin, causing hypoglycemia. It typically presents as a solitary benign tumor but can be associated with multiple endocrine neoplasia type 1 (MEN1). … child toxicityNettet25. nov. 2024 · Insulinoma-associated 1. A novel marker in Merkel cell carcinoma (cutaneous neuroendocrine carcinoma). J Cutaneous Pathology, 45, 129–135. CrossRef PubMed Google Scholar Tanigawa, M., Nakayama, M., Taira, T., et al. (2024). … gpib cls